Severe Gout
نویسندگان
چکیده
منابع مشابه
Urate oxidase (rasburicase) for treatment of severe tophaceous gout.
Gout is a clinical disorder caused by deposition of urate crystals in a joint leading to acute inflammatory response with acute pain. In severe and longstanding gout, the crystals accumulate in soft tissues such as cartilage, subcutaneous tissue or even veins leading to the development of tophi responsible for very large deposit formations and disability. Most cases of gout present with the sud...
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Gout is the most prevalent form of inflammatory arthropathy. Several studies suggest that its prevalence and incidence have risen in recent decades. Numerous risk factors for the development of gout have been established, including hyperuricaemia, genetic factors, dietary factors, alcohol consumption, metabolic syndrome, hypertension, obesity, diuretic use and chronic renal disease. Osteoarthri...
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Imaging is a helpful tool for clinicians to evaluate diseases that induce chronic joint inflammation. Chronic gout is associated with changes in joint structures that may be evaluated with diverse imaging techniques. Plain radiographs show typical changes only in advanced chronic gout. Computed tomography may best evaluate bone changes, whereas magnetic resonance imaging is suitable to evaluate...
متن کاملGout. Mechanisms of inflammation in gout
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activat...
متن کاملJuvenile gout.
The rarity of gout in children prompts the following report of two cases, both apparently 'primary' in nature. On occasion juvenile gout may result from a demonstrable cause, falling into the 'secondary' category. In secondary gout both blood and urinary levels of uric acid tend to be higher than in primary gout, and the ratio of renal clearance of uric acid to glomerular filtration rate is usu...
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ژورنال
عنوان ژورنال: International Journal of Clinical & Medical Imaging
سال: 2019
ISSN: 2376-0249
DOI: 10.4172/2376-0249.1000632